MUCOADHESIVE BUCCAL FILMS OF GLIBENCLAMIDE DEVELOPMENT AND EVALUATION

Surface pH of buccal films was found to be 6. The mechanism of drug release whether diffusion, swelling, or erosion was confirmed by Higuchi’s plots showing the graphical representation of cumulative percentage drug release vs. The drug delivery system was formulated as a matrix. Development of anticandidal delivery systems: The breaking time was considered as the end point. The water-soluble hydrophilic additive dissolves rapidly, resulting in high porosity. The swollen films were then reweighed W2 and the swelling index SI was calculated using the following formula. The amount and properties of the incorporated drug determine matrix integrity.

Novel concept for a mucosal adhesive ointment. Research Article Open Access. Formulation and characterization of a buccoadhesive enteric tablet for the treatment of oral lesions. The addition of the water-insoluble drug increased water uptake of the film. Int J Drug Deliv. Authors are thankful to the Department of Veterinary Pharmacology and Toxicology, Veterinary College, Bangalore, for providing all facilities in carrying out this study. Swelling percentage, X t:

It was found that the drug release from the films varied with respect to the proportion of polymers. It may also be possible to circumvent the hepatic first-pass effect by administering the drug through buccal mucosa, which is richly perfuse with blood vessels and offers greater permeability than the skin. Preliminary studies done with the groups of formulations, from which these 4 formulations were selected, showed that increase in the polymer concentration reduced the diffusion of drug from the matrix [ Figure 1 ].

The visual observations of the thin films were showed that, there was no difference among the PVP and GLB thin film with respect to colour, flexibility, surface uniformity and transparency Figure 1.

Higuchi plots for selected formulations of glibenclamide buccal develompent. The weight of swollen film after time t, and X 0: Buccoadhesive erodible disk for the treatment of oral infections: Merck P Ltd, Mumbai.

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Film forming gel for treatment of oral mucositis: Nil Conflict of Interest: The membrane was washed with distilled water and then with phosphate buffer pH 6.

The GLB pure drug Figure 3a showed characteristic amide peaks at Other imperative peaks at In order to reduce the dosing frequency, improve patient compliance and drug dissolution or bioavailability of GLB, several strategies have been used by the researchers, such as micronization [ 8 ], developnent [ 3 ], molecular dispersion [ 9 ], modification of crystal habits of drug substances [ 1011 ], salt selection and amorphization of the compound [ 1011 ], polymorphism [ 12 ], use of surfactants [ 13 ], glass formation [ 14 ], oil-in-water emulsion [ 15 ], freeze-drying [ 16 ] etc.

The films were characterized for their physical characteristics, release characteristics, such as surface pH, thickness, folding endurance, drug content uniformity, and percentage swelling [ Table 1 ].

Mucoadhesive buccal films of glibenclamide: Development and evaluation.

The thickness of oral thin films was measured in triplicate by using calibrated digital Verniar calipers MitutoyoMitutoyo, Japan and mean value of xevelopment was recorded [ 26 ]. Drug Dev Ind Pharm. II Mucoadhesive devices for prolonged drug delivery in the oral cavity.

This arrangement was later sunken to 50 ml of simulated salivary medium. Physico-chemical properties of water insoluble polymers important to mucin epithelial adhesion. In addition, they can circumvent the relatively short residence time of oral gels on the mucosa, which are easily washed away and removed by saliva.

Mucoadhesive buccal films of glibenclamide: Development and evaluation.

The surface morphology of the GLB pure drug Figures 2a and 2b and GLB thin film Figures 2c and 2d with low and high magnification respectively were represented in Figure 2. Glibenclamide is an oral hypoglycemic drug completely metabolized in the liver, the principal metabolite being very weakly active, buccal delivery may be useful for the treatment of diabetes more effectively.

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Prepared films were evaluated for weight, thickness, surface pH, swelling index SIfolding endurance, drug content uniformity, in vitro release, and ex vivo permeation studies. All the tests were performed for four times and mean of the values was reported [ 27 ].

The dissolution rate of GLB thin film at 1 h pH 5.

Mucoadhesive buccal films of glibenclamide: Development and evaluation

The prepared thin films were elegant enough, transparent, flexible, smooth and homogeneous [ 36 ]. Indian Evaluuation Pharm Sci. The surface pH of all the films was within the range of salivary pH 6.

Enhanced bioavailability by buccal administration of triamcinalone acetonide from the bioadhesive gels in rabbits. The film thickness and weight increased with increasing polymer content. The employed polymers should be non-toxic, non-irritant, and non-immunogenic mucoaxhesive nature to prepare oral thin films [ 18 ].

The thin films were mucoadhseive evaluated for in vitro drug release and in vivo insulin release process. A sample of 4 cm 2 square of thin film was dissolved in 10 ml methanol and shaken it for 5 min to extract drug from the formulation.

Development and Evaluation of Polymer-bound Glibenclamide Oral Thin Film | OMICS International

The Higuchi plots were found to be linear with correlation coefficient values of 0. Glibenclamide is a second generation and one of the most potent sulfonylurea used in the treatment of maturity-onset diabetes as an oral hypoglycemic agent.

The folding endurance of the drug loaded thin films was estimated and was found to be